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Phosphorothioate Bonds Modifications

Phosphorothioate Bond

The phosphorothioate (PS) bond substitutes a sulfur atom for a non-bridging oxygen in the phosphate backbone of an oligo. This modification renders the internucleotide linkage resistant to nuclease degradation. Phosphorothioate bonds can be introduced between the last 3-5 nucleotides at the 5'- or 3'-end of the oligo to inhibit exonuclease degradation. Including phosphorothioate bonds throughout the entire oligo will help reduce attack by endonucleases as well.

Phosphorothioate Bond Entry
Bond NameSymbolExample
Phosphorothioated DNA bases _* e.g. A*
Phosphorothioated RNA bases r_* e.g. rA*
Phosphorothioated 2' O-methyl bases m_* e.g. mA*
Phosphorothioated Affinity Plus (locked nucleic acid) bases +_* e.g. +A*
Pricing Details (price per bond)
Product Pricing Order
100 nmole DNA Oligo2,90 € EURAdd to Order
250 nmole DNA Oligo2,90 € EURAdd to Order
1 umole DNA Oligo4,05 € EURAdd to Order
2 umole DNA Oligo8,50 € EURAdd to Order
5 umole DNA Oligo17,50 € EURAdd to Order
10 umole DNA Oligo24,00 € EURAdd to Order
100 nmole RNA Oligo2,90 € EURAdd to Order
250 nmole RNA Oligo2,90 € EURAdd to Order
1 umole RNA Oligo4,05 € EURAdd to Order
5 umole RNA Oligo17,50 € EURAdd to Order
10 umole RNA Oligo24,00 € EURAdd to Order
100 nmole DNA Plate Oligo2,90 € EURAdd to Order
250 nmole DNA Plate Oligo2,90 € EURAdd to Order
1 umole DNA Plate Oligo4,05 € EURAdd to Order
4 nmole Ultramer® DNA Oligo2,90 € EURAdd to Order
4 nmole Ultramer® DNA Plate Oligo2,90 € EURAdd to Order
20 nmole Ultramer® DNA Oligo2,90 € EURAdd to Order
20 nmole Ultramer® DNA Plate Oligo2,90 € EURAdd to Order
 
 
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