Large-scale synthesis

Manufacturing capabilities

Numerous collaborations with our customers have enabled us to optimize our manufacturing processes and platforms for bulk synthesis of various types of oligos. Our large-scale capabilities range from standard, unmodified oligos to highly complex oligos for high-throughput, diagnostic, and other commercial applications. You can acquire milligram to gram quantities of highly pure nucleic acids, including aptamers, ribozymes, miRNAs and siRNAs, next generation sequencing adapters, PCR primers, and dual-labeled probes.

Additional features of our large-scale offerings include:

• Final yields from 25 mg to 10 g
• Standard DNA and RNA bases, modified bases, chemical modifications, linkers, and fluorophores
• Unmodified DNA lengths between 4–100 bases
• Unmodified RNA lengths between 4–70 bases
• GMP manufacturing available for customers requiring controlled processes and traceability
• Turnaround times with delivery in as few as 10 business days

Additional services

In addition to using industry-leading oligos, when you work with our team of large-scale experts you will benefit from a variety of personalized services. These include:

• Confidential, application-specific guidance for your transition from small- to large-scale production
• Flexible ordering methods
• Custom purification options and purity specifications
• Formulation services for the creation of oligo pools, primer mixes, assays, and duplexes
• Custom vialing and plating options with consistent or variable fill sizes
• Verification and release of product compliance before shipment
• Hard-copy analytical QC documentation and certificates of analysis

To learn more about these individual services, click here.