Large-scale oligo synthesis

Overview

Manufacturing capabilities

Numerous collaborations with our customers have enabled us to optimize our manufacturing processes and platforms for bulk synthesis of various types of oligos. Our large-scale capabilities range from standard, unmodified oligos to highly complex oligos for high-throughput, and other commercial applications. You can acquire milligram to gram quantities of highly pure nucleic acids, including aptamers, ribozymes, miRNAs and siRNAs, next generation sequencing adapters, PCR primers, and dual-labeled probes.

Additional features of our large-scale offerings include:

• Final yields from 25 mg to 10 g
• Standard DNA and RNA bases, modified bases, chemical modifications, linkers, and fluorophores
• Unmodified DNA lengths between 4−100 bases
• Unmodified RNA lengths between 4−70 bases
• GMP manufacturing available for customers requiring controlled processes and traceability

Additional services

In addition to using industry-leading oligos, when you work with our team of large-scale experts you will benefit from a variety of personalized services.

These include:

• Confidential, application-specific guidance for your transition from small- to large-scale production
• Flexible ordering methods
• Custom purification options and purity specifications
• Formulation services for the creation of oligo pools, primer mixes, assays, and duplexes
• Custom vialing and plating options with consistent or variable fill sizes
• Verification and release of product compliance before shipment
• Hard-copy analytical QC documentation and certificates of analysis

Learn more about these individual services here.

GMP

Our GMP products and services are customized to your exact specifications with the documentation required for components used in commercial and molecular applications. Learn more about our GMP capabilities here.