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Our Scientific Applications Support team has assembled a list of frequently asked questions to help you find answers quickly. Filter using one or more categories to focus on specific topics, or use the search bar to perform a text search.
Is it possible to order an oligo with both an amino modifier modification and a modification attached via NHS Ester chemistry?
Unfortunately, we are not able to provide oligos with both a free amine and an NHS ester modification. The NHS ester will bind to any free amino group as it is attached to the oligo post synthesis.
IDT recommends using a modification that is attached via a different chemistry, such as Click chemistry or phosphoramidite chemistry.