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Frequently asked questions

Our Scientific Applications Support team has assembled a list of frequently asked questions to help you find answers quickly. Filter using one or more categories to focus on specific topics, or use the search bar to perform a text search.

Should pegRNAs for CRISPR prime editing include chemical modifications?

We have found that including three 2'OMe bases and three phosphorothioate linkages on each end of the pegRNA results in higher levels of CRISPR prime editing.