Processing
Phosphorothioate Bonds Modifications
Phosphorothioate Bond
The phosphorothioate (PS) bond substitutes a sulfur atom for a non-bridging oxygen in the phosphate backbone of an oligo. This modification renders the internucleotide linkage resistant to nuclease degradation. Phosphorothioate bonds can be introduced between the last 3-5 nucleotides at the 5'- or 3'-end of the oligo to inhibit exonuclease degradation. Including phosphorothioate bonds throughout the entire oligo will help reduce attack by endonucleases as well.
| Bond Name | Symbol | Example |
|---|---|---|
| Phosphorothioated DNA bases | _* | e.g. A* |
| Phosphorothioated RNA bases | r_* | e.g. rA* |
| Phosphorothioated 2' O-methyl bases | m_* | e.g. mA* |
| Phosphorothioated Affinity Plus (locked nucleic acid) bases | +_* | e.g. +A* |
| Product | Pricing | Order |
|---|---|---|
| 100 nmole DNA Oligo | 3,14 € EUR | Add to Order |
| 250 nmole DNA Oligo | 3,14 € EUR | Add to Order |
| 1 umole DNA Oligo | 4,37 € EUR | Add to Order |
| 2 µmole DNA Oligo | 9,00 € EUR | Add to Order |
| 5 umole DNA Oligo | 18,50 € EUR | Add to Order |
| 10 umole DNA Oligo | 26,00 € EUR | Add to Order |
| 100 nmole RNA Oligo | 3,14 € EUR | Add to Order |
| 250 nmole RNA Oligo | 3,14 € EUR | Add to Order |
| 1 umole RNA Oligo | 4,37 € EUR | Add to Order |
| 5 umole RNA Oligo | 18,50 € EUR | Add to Order |
| 10 umole RNA Oligo | 26,00 € EUR | Add to Order |
| 100 nmole DNA Plate Oligo | 3,14 € EUR | Add to Order |
| 250 nmole DNA Plate Oligo | 3,14 € EUR | Add to Order |
| 1 umole DNA Plate Oligo | 4,37 € EUR | Add to Order |
| 4 nmole Ultramer™ DNA Oligo | 3,14 € EUR | Add to Order |
| 20 nmole Ultramer™ DNA Oligo | 3,14 € EUR | Add to Order |
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